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CTDP1 / FCP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.
| Gene Name: | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
| Family/Subfamily: | Protein Phosphatase , Protein Phosphatase - Serine/Threonine other |
| Synonyms: | CTDP1, CCFDN, CTD phosphatase, FCP1, Serine phosphatase FCP1a, CTD Phosphatase subunit 1 |
| Target Sequences: | NM_004715 NP_004706.3 Q9Y5B0 |
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