CTCFL / BORIS

CCCTC-binding factor (zinc finger protein)-like

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

CTCFL / BORIS (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

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Human CTCFL / BORIS Protein (Recombinant GST, N-terminus) (aa193-293) - LS-G63685

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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CTCFL / BORIS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107864

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.6 kDa

Price:

100 µg/$710

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Mouse CTCFL / BORIS Protein (Recombinant His-SUMO) (Full Length) - LS-G20641

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

89.06 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Mouse CTCFL / BORIS Protein (Recombinant His) (Full Length) - LS-G22879

Source:

Yeast

Tag:

His

Molecular Weight:

75.11 kD

Price:

1 mg/$1,683; 100 µg/$499; 20 µg/$364

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Human CTCFL / BORIS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92899

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.6 kDa

Price:

20 µg/$215

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