Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

CSNK2A1

casein kinase 2, alpha 1 polypeptide

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.

Gene Name: casein kinase 2, alpha 1 polypeptide
Family/Subfamily: Protein Kinase , Casein kinase II
Synonyms: CSNK2A1, Casein kinase II alpha, Casein kinase II subunit alpha, Ck2 alpha, CK2 catalytic subunit alpha, CKII, CKIIalpha, CK2A1, CKII alpha, Protein kinase CK2, Casein kinase 2 alpha, CK II alpha
Target Sequences: NM_001895 NP_001886.1 P68400

☰ Filters
Products
Proteins (14)
Over-Expression Lysate (2)
Recombinant (12)
CSNK2A1 (14)
No (14)
GST (1)
GST, N-terminus (2)
His (2)
His, N-Terminal (1)
His-GST (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (10)
Mouse (2)
293T Cells (1)
Baculovirus (1)
E. coli (4)
HEK 293 Cells (2)
Insect Cells (3)
Sf21 Cells (1)
Wheat Germ Extract (2)
Purified (5)
Low endotoxin level (3)
Biologically active (1)
CSNK2A1 Protein - 12.5% SDS-PAGE of human CSNK2A1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
71.5 kDa
10 µg/$461; 25 µg/$611
CSNK2A1 Protein
Select
E. coli
His-SUMO
61.11 kD
1 mg/$1,152; 100 µg/$400; 20 µg/$307
CSNK2A1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$461; 25 µg/$611
CSNK2A1 Protein - Purified recombinant protein CSNK2A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
45 kDa
20 µg/$922
Select
Insect Cells
None
Biologically active
~70 kDa
10 µg/$407
Select
Insect Cells
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
71.4 kDa
20 µg/$542; 50 µg/$664
CSNK2A1 Protein
Select
E. coli
His, N-Terminal
29 kDa
50 µg/$373
Select
Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
72.9 kDa
20 µg/$542; 50 µg/$664
Select
Insect Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
45.3 kDa
20 µg/$492; 50 µg/$587
CSNK2A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45 kDa
100 µg/$435
CSNK2A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
45 kDa
20 µg/$125
CSNK2A1 Protein
Select
E. coli
His
100 µg/$401; 500 µg/$925
CSNK2A1 Protein
Select
E. coli
His
50 µg/$351; 250 µg/$694
Select
Sf21 Cells
None
70.0 kDa
5 µg/$466
Viewing 1-14 of 14 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).