CSF1R / CD115 / FMS

colony stimulating factor 1 receptor

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

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Products

Proteins (30)

Type

Over-Expression Lysate (2)

Recombinant (28)

Target

CSF1R / CD115 / FMS (30)

Application

Bind (3)

ELISA (2)

Func (2)

SDS-PAGE (8)

Publications

No (30)

Tag

6His, C-terminus (3)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

Fc, C-terminus (4)

GST, N-terminus (1)

His (5)

His,C-terminus (5)

His-GST (1)

His-GST, N-terminus (1)

His-SUMO (1)

Human IgG Fc, C-terminus (2)

Mouse IgG2a Fc, C-terminus (1)

Myc-DDK (Flag) (3)

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Species

Cat (1)

Crab-eating macaque (2)

Human (19)

Mouse (4)

Rat (3)

Source

293T Cells (1)

Baculovirus (2)

E. coli (4)

HEK 293 Cells (14)

Human Cells (3)

Mammalian Cells (4)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (20)

Biologically Active

Biologically active (7)

Select

Mouse CSF1R / CD115 / FMS Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Ser511) - LS-G141233

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse CSF1R consists of 730 amino acids and predicts a molecular mass of 81.9 kDa.

Price:

100 µg/$441; 1 mg/$2,003

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Human CSF1R / CD115 / FMS Protein (Recombinant 6His, C-terminus) (Met1-Glu512) - LS-G97688

Source:

HEK 293 Cells

Tag:

6His, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56 kDa

Price:

100 µg/$483

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Rat CSF1R / CD115 / FMS Protein (Recombinant His) (Met1-Glu510) - LS-G98371

Source:

HEK 293 Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.5 kDa

Price:

100 µg/$721

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Mouse CSF1R / CD115 / FMS Protein (Recombinant His) (aa639-868) - LS-G13909

Source:

E. coli

Tag:

His

Molecular Weight:

27.2 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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Human CSF1R / CD115 / FMS Protein (Recombinant His,C-terminus) (Met1-Glu512) - LS-G47304

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mature human M-CSF R comprises 499 amino acids with a calculated molecular mass of 55.1 kDa. Due to glycosylation, the apparent molecular mass of rhM-CSFR is approximately 80-90 kDa in SDS-PAGE under reducing conditions.

Price:

200 µg/$441

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Human CSF1R / CD115 / FMS Protein (Recombinant His-GST, N-terminus) (Lys543-Cys972) - LS-G47307

Source:

Baculovirus

Tag:

His-GST, N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human CSF1R (aa 543-972) /GST chimera consists of 667 amino acids and has a calculated molecular mass of 76 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.

Price:

50 µg/$410

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Human CSF1R / CD115 / FMS Protein (Recombinant His,C-terminus) (Met1-Glu512) - LS-G47288

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human M-CSFR contains 504 amino acids after the removal of signal peptide with a calculated molecular mass of 56 kDa. As a result of glycosylation, it migrates as an approximately 85-95 kDa protein in SDS-PAGE under reducing conditions.

Price:

100 µg/$348; 1 mg/$1,345

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Human CSF1R / CD115 / FMS Protein (Recombinant His,C-terminus) (Met1-Ser290) - LS-G141228

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human CSF1R consists of 282 amino acids and predicts a molecular mass of 31.1 kDa.

Price:

200 µg/$441

Select

Human CSF1R / CD115 / FMS Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Glu512) - LS-G141231

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human CSF1R consists of 731 amino acids and predicts a molecular mass of 81.2 kDa.

Price:

100 µg/$364; 1 mg/$1,452

Select

Human CSF1R / CD115 / FMS Protein (Recombinant Mouse IgG2a Fc, C-terminus) (Met1-Pro517) - LS-G141240

Source:

HEK 293 Cells

Tag:

Mouse IgG2a Fc, C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human CSF1R consists of 731 amino acids and predicts a molecular mass of 81.5 kDa.

Price:

100 µg/$410; 1 mg/$1,735

Select

Human CSF1R / CD115 / FMS Protein (Recombinant DDK,C-terminus) - LS-G142369

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

55.1 kDa

Price:

20 µg/$677

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Human CSF1R / CD115 / FMS Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142197

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

58 kDa

Price:

20 µg/$1,107

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Cat CSF1R / CD115 / FMS Protein (Recombinant His-SUMO) (aa20-514) - LS-G20633

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

70.7 kD

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Mouse CSF1R / CD115 / FMS Protein (Recombinant His,C-terminus) (Met1-Ser511) - LS-G51375

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant mouse CSF1R consists of 503 amino acids and has a predicted molecular mass of 56.8 kDa. As a result of glycosylation, the apparent molecular mass of rm CSF1R is approximately 80-90 kDa in SDS-PAGE under reducing conditions.

Price:

100 µg/$410; 1 mg/$1,735

Select

Human CSF1R / CD115 / FMS Protein (Recombinant GST, N-terminus) (aa21-120) - LS-G58236

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human CSF1R / CD115 / FMS Protein (Recombinant His-GST) (Lys543-Cys972) - LS-G97347

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

76 kDa

Price:

50 µg/$707

Select

Human CSF1R / CD115 / FMS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66216

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

107.8 kDa

Price:

20 µg/$1,107

Select

Mouse CSF1R / CD115 / FMS Protein (Recombinant His) (Met1-Ser511) - LS-G98745

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.8 kDa

Price:

100 µg/$843

Select

Rat CSF1R / CD115 / FMS Protein (Recombinant Fc, C-terminus) (Met1-Glu510) - LS-G138194

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82 kDa

Price:

100 µg/$721

Select

Human CSF1R / CD115 / FMS Protein (Recombinant 6His, C-terminus) (Ile20-Pro517) - LS-G40299

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

55.9kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$725; 1 mg/$1,113

Select

Human CSF1R / CD115 / FMS Protein (Recombinant Fc, C-terminus) (Ile20-Pro517) - LS-G40366

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

81.9kD

Price:

10 µg/$248; 50 µg/$302; 500 µg/$820; 1 mg/$1,203

Select

Human CSF1R / CD115 / FMS Protein (Recombinant 6His, C-terminus) (Ile20-Pro517) - LS-G138610

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

55.9 kDa

Price:

10 µg/$248; 50 µg/$288

Select

Human CSF1R / CD115 / FMS Protein (Recombinant Fc, C-terminus) (Ile20-Pro517) - LS-G138683

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

81.9 kDa

Price:

10 µg/$248; 50 µg/$300

Select

Crab-eating macaque CSF1R / CD115 / FMS Protein (Recombinant Fc, C-terminus) (Ile20-Pro517) - LS-G139403

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82.2 kDa

Price:

10 µg/$277; 50 µg/$389

Select

Crab-eating macaque CSF1R / CD115 / FMS Protein (Recombinant His,C-terminus) (Ile20-Pro517) - LS-G139903

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.1 kDa

Price:

10 µg/$288; 50 µg/$436

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