CRYAA / Alpha A Crystallin

crystallin, alpha A

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

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Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

CRYAA / Alpha A Crystallin (9)

Publications

No (9)

Tag

6His, C-terminus (2)

GST (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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CRYAA / Alpha A Crystallin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123213

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

100 µg/$494

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Human CRYAA / Alpha A Crystallin Protein - LS-G134041

Source:

E. coli

Tag:

None

Molecular Weight:

19.9 kDa

Price:

20 µg/$329; 100 µg/$412; 1000 µg/$1,515

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Human CRYAA / Alpha A Crystallin Protein (Recombinant 6His, C-terminus) (Met1-Ser173) - LS-G138578

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.9 kDa

Price:

10 µg/$233; 50 µg/$277

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Human CRYAA / Alpha A Crystallin Protein (Recombinant GST) (Full Length) - LS-G28037

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CRYAA / Alpha A Crystallin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74409

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

20 µg/$150

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Human CRYAA / Alpha A Crystallin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64891

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

20 µg/$1,107

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Human CRYAA / Alpha A Crystallin Protein (Recombinant 6His, C-terminus) (Met1-Ser173) - LS-G39621

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.9kD

Price:

10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113

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Human CRYAA / Alpha A Crystallin Protein (Recombinant His, N-Terminal) (Asp2-Ser173) - LS-G132971

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

21.3kDa

Price:

10 µg/$280; 50 µg/$437; 200 µg/$872; 100 µg/$700; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,489

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Human CRYAA / Alpha A Crystallin Protein (Recombinant) - LS-G3377

Source:

E. coli

Tag:

None

Price:

100 µg/$311; 20 µg/$245; 1 mg/$511

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