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CRLF3 is a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5.
Gene Name: | cytokine receptor-like factor 3 |
Synonyms: | CRLF3, CREME9, CRLM9, FRWS, p48, CREME-9, CYTOR4, p48.2 |
Target Sequences: | NM_015986 NP_057070.3 Q8IUI8 |
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