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CRKL

v-crk avian sarcoma virus CT10 oncogene homolog-like

CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

Gene Name: v-crk avian sarcoma virus CT10 oncogene homolog-like
Synonyms: CRKL, Crk-like protein
Target Sequences: NM_005207 NP_005198.1 P46109

Publications (1)

1
A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development. Miller KA, Tan TY, Welfare MF, White SM, Stark Z, Savarirayan R, Burgess T, Heggie AA, Caruana G, Bertram JF, Bateman JF, Farlie PG. Molecular syndromology. 2014 5:276-86. (WB; Human) [PubMed:25565927] Related Antibodies: LS-C14694.

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Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
CRKL (9)
No (9)
GST (1)
GST, N-terminus (1)
His (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (8)
293T Cells (1)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (2)
CRKL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.6 kDa
100 µg/$494
CRKL Protein - Recombinant  Crk Like Protein By SDS-PAGE
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E. coli
His-T7
37.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CRKL Protein - 12.5% SDS-PAGE of human CRKL stained with Coomassie Blue
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Wheat Germ Extract
GST
60.2 kDa
10 µg/$479; 25 µg/$670
CRKL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.6 kDa
20 µg/$150
CRKL Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CRKL Protein - Purified recombinant protein CRK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
22.7 kDa
20 µg/$1,107
CRKL Protein - Purified recombinant protein CRK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
33.7 kDa
20 µg/$1,107
CRKL Protein - Purified recombinant protein CRKL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
33.6 kDa
20 µg/$1,107
CRKL Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Viewing 1-9 of 9 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).