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CRKL

v-crk avian sarcoma virus CT10 oncogene homolog-like

CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

Gene Name:	v-crk avian sarcoma virus CT10 oncogene homolog-like
Synonyms:	CRKL, Crk-like protein
Target Sequences:	NM_005207 NP_005198.1 P46109

Publications (1)

A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development. Miller KA, Tan TY, Welfare MF, White SM, Stark Z, Savarirayan R, Burgess T, Heggie AA, Caruana G, Bertram JF, Bateman JF, Farlie PG. Molecular syndromology. 2014 5:276-86. (WB; Human) [PubMed:25565927] Related Antibodies: LS-C14694.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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