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CRH / CRF

corticotropin releasing hormone

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.

Gene Name: corticotropin releasing hormone
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: CRH, CRF, Corticoliberin
Target Sequences: NM_000756 NP_000747.1 P06850

Publications (2)

1
Expression of Stress-Mediating Genes is Increased in Term Placentas of Women with Chronic Self-Perceived Anxiety and Depression. Cristina A Martinez, Ina Marteinsdottir, Ann Josefsson, Gunilla Sydsjö, Elvar Theodorsson, Heriberto Rodriguez-Martinez. Genes. 2020 July;11: [Full Text Article] [PubMed:32752005] [PMC:PMC7463995] Related Antibodies: LS-B11889.
2
Circulating levels of urocortin neuropeptides are impaired in children with overweight. Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Sriraman Devarajan, Samia Warsame, Hessa AlKandari, Maria AlMahdi, Heikki A Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tiss. Obesity (Silver Spring, Md.). 2022 Feburary;30:472-481. [Full Text Article] [PubMed:35088550] [PMC:PMC9305428]

☰ Filters
Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
CRH / CRF (13)
No (13)
GST (1)
GST, N-terminus (1)
His (4)
His, N-Terminal (1)
His-GST (3)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (7)
Mouse (3)
Rat (2)
293T Cells (1)
E. coli (9)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (1)
CRH / CRF Protein - Recombinant Corticotropin Releasing Hormone By SDS-PAGE
Select
E. coli
His-GST
46.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
CRH / CRF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.42 kDa
100 µg/$494
CRH / CRF Protein
Select
E. coli
His
18.8 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
CRH / CRF Protein - Recombinant Corticotropin Releasing Hormone By SDS-PAGE
Select
E. coli
His-T7
21.1 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
CRH / CRF Protein - Recombinant Corticotropin Releasing Hormone By SDS-PAGE
Select
E. coli
His
16.4 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
E. coli
His
18.3 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
CRH / CRF Protein - Recombinant Corticotropin Releasing Hormone By SDS-PAGE
Select
E. coli
His-GST
48.7 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
CRH / CRF Protein - Recombinant Corticotropin Releasing Hormone By SDS-PAGE
Select
E. coli
His-GST
49.2 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
CRH / CRF Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CRH / CRF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21.42 kDa
20 µg/$150
Select
E. coli
186 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
20.57 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
CRH / CRF Protein
Select
E. coli
His, N-Terminal
18.9 kDa
50 µg/$419
CRH / CRF Protein - 12.5% SDS-PAGE of human CRH stained with Coomassie Blue
Select
Wheat Germ Extract
GST
47.8 kDa
2 µg/$439
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).