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CRH / CRF

corticotropin releasing hormone

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.

Gene Name: corticotropin releasing hormone
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: CRH, CRF, Corticoliberin
Target Sequences: NM_000756 NP_000747.1 P06850

Publications (2)

1
Expression of Stress-Mediating Genes is Increased in Term Placentas of Women with Chronic Self-Perceived Anxiety and Depression. Cristina A Martinez, Ina Marteinsdottir, Ann Josefsson, Gunilla Sydsjö, Elvar Theodorsson, Heriberto Rodriguez-Martinez. Genes. 2020 July;11: [Full Text Article] [PubMed:32752005] [PMC:PMC7463995] Related Antibodies: LS-B11889.
2
Circulating levels of urocortin neuropeptides are impaired in children with overweight. Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Sriraman Devarajan, Samia Warsame, Hessa AlKandari, Maria AlMahdi, Heikki A Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tiss. Obesity (Silver Spring, Md.). 2022 Feburary;30:472-481. [Full Text Article] [PubMed:35088550] [PMC:PMC9305428]

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ELISA Kits (24)
Competitive EIA (21)
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CRH / CRF (24)
Human (4)
Mouse (6)
Rat (4)
Chicken (1)
Dog (1)
Monkey (1)
Pig (2)
Porcine (1)
Rabbit (1)
Sheep (2)
12 x 8-Well Microstrips (1)
96-Well Strip Plate (23)
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Yes (1)
Plasma (18)
Serum (18)
Tissue Homogenates (6)
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
2.188 - 140 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
3.91 - 250 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Monkey
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rabbit
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
CRH / CRF ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
CRH / CRF ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
25 - 500 nmol/l
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CRH / CRF ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
2.5 - 40 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$958
CRH / CRF ELISA Kit
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Competitive EIA
12 x 8-Well Microstrips
Sheep
14 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Sheep
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Pig
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$889
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).