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Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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CPB2 / TAFI
carboxypeptidase B2 (plasma)
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants.
| Gene Name: | carboxypeptidase B2 (plasma) |
| Family/Subfamily: | Exopeptidase , Metallopeptidase M14 |
| Synonyms: | CPB2, Carboxypeptidase R, Carboxypeptidase U, Carboxypeptidase B-like, Carboxypeptidase B2 (plasma), TAFI, Plasma carboxypeptidase B, Carboxypeptidase B2, CPU, PCPB |
| Target Sequences: | M75106 NP_001863.3 Q96IY4 |
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