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Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants.
Gene Name: | carboxypeptidase B2 (plasma) |
Family/Subfamily: | Exopeptidase , Metallopeptidase M14 |
Synonyms: | CPB2, Carboxypeptidase R, Carboxypeptidase U, Carboxypeptidase B-like, Carboxypeptidase B2 (plasma), TAFI, Plasma carboxypeptidase B, Carboxypeptidase B2, CPU, PCPB |
Target Sequences: | M75106 NP_001863.3 Q96IY4 |
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