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Collagen IV

Type IV Collagen (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina. Collagen IV is the more common usage, as opposed to the older terminology of 'type-IV collagen'.There are six human genes associated with it: COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6

Collagen IV Target Details

Target Name: Collagen IV

Publications (5)

1
Vascular gene expression patterns are conserved in primary and metastatic brain tumors. Liu Y, Carson-Walter EB, Cooper A, Winans BN, Johnson MD, Walter KA. Journal of neuro-oncology. 2010 99:13-24. (IHC-P; Human) [Full Text Article] [PubMed:20063114] [PMC:PMC2904485]
2
Bioengineering Human Myocardium on Native Extracellular Matrix. Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okamoto T, Gonzalez G, Milan DJ, Gaudette GR, Ott HC. Circulation research. 2016 January;118:56-72. [Full Text Article] [PubMed:26503464] [PMC:PMC4740234]
3
ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Yu Yamazaki, Mitsuru Shinohara, Akari Yamazaki, Yingxue Ren, Yan W Asmann, Takahisa Kanekiyo, Guojun Bu. Arteriosclerosis, thrombosis, and vascular biology. 2020 January;40:128-144. [Full Text Article] [PubMed:31665905] [PMC:PMC7007705]
4
Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats. Edwin K Jackson, Zaichuan Mi, Delbert G Gillespie, Dongmei Cheng, Stevan P Tofovic. Journal of the American Heart Association. 2021 March;10:e020088. [Full Text Article] [PubMed:33682436] [PMC:PMC8174220]
5
Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Song JJ, Guyette JP, Gilpin SE, Gonzalez G, Vacanti JP, Ott HC. Nature medicine. 2013 May;19:646-51. [Full Text Article] [PubMed:23584091] [PMC:PMC3650107] Related Antibodies: LS-B7348.
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).