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CNOT7

CCR4-NOT transcription complex, subunit 7

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Gene Name: CCR4-NOT transcription complex, subunit 7
Synonyms: CNOT7, BTG1-binding factor 1, BTG1 binding factor 1, CAF-1, CCR4-associated factor 1, CAF1, HCAF-1
Target Sequences: NM_013354 NP_037486.2 Q9UIV1

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Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
CNOT7 (7)
No (7)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (5)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
CNOT7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CNOT7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
28 kDa
100 µg/$494
CNOT7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
100 µg/$494
CNOT7 Protein - Purified recombinant protein CNOT7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$1,107
CNOT7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$150
CNOT7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
28 kDa
20 µg/$150
CNOT7 Protein - 12.5% SDS-PAGE of human CNOT7 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
57.09 kDa
10 µg/$479; 25 µg/$670
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).