CML / BCR

breakpoint cluster region

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CML / BCR (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human CML / BCR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65100

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

137.5 kDa

Price:

20 µg/$1,107

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CML / BCR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110649

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

137.5 kDa

Price:

100 µg/$710

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Human CML / BCR Protein (Recombinant His-T7) (aa1042-1243) - LS-G24787

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.3 kDa

Price:

10 µg/$274; 50 µg/$397; 100 µg/$635; 200 µg/$792; 1 mg/$1,864; 500 µg/$1,419; 5 mg/$2,826; 2 mg/$2,047

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Human CML / BCR Protein (Recombinant GST, N-terminus) (aa182-280) - LS-G57886

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CML / BCR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74855

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

137.5 kDa

Price:

20 µg/$215

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Mouse CML / BCR Protein (Recombinant) (Met1042-Thr1268) - LS-G133680

Source:

E. coli

Tag:

None

Molecular Weight:

29.2kDa

Price:

10 µg/$277; 50 µg/$417; 200 µg/$832; 100 µg/$667; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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