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CLP / COTL1

coactosin-like 1 (Dictyostelium)

CLP / COTL1 is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

Gene Name:	coactosin-like 1 (Dictyostelium)
Synonyms:	COTL1, CLP, Coactosin-like protein
Target Sequences:	NM_021149 NP_066972.1 Q14019

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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