CLNS1A

chloride channel, nucleotide-sensitive, 1A

Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CLNS1A (4)

Publications

No (4)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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CLNS1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118654

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26 kDa

Price:

100 µg/$494

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Human CLNS1A Protein (Recombinant GST) (Full Length) - LS-G27956

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CLNS1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75172

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26 kDa

Price:

20 µg/$150

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Human CLNS1A Protein (Recombinant His) - LS-G2017

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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