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Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Gene Name: | CDC-like kinase 4 |
Family/Subfamily: | Protein Kinase , LAMMER/Clk |
Synonyms: | CLK4, CDC-like kinase 4 |
Target Sequences: | NM_020666 NP_065717.1 Q9HAZ1 |
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