CLK2

CDC-like kinase 2

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CLK2 (6)

Publications

No (6)

Tag

6His-B2M, N-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human CLK2 Protein (Recombinant 6His-B2M, N-terminus) - LS-G136985

Source:

E. coli

Tag:

6His-B2M, N-terminus

Molecular Weight:

56.7 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human CLK2 Protein (Recombinant 6His-SUMO, N-terminus) - LS-G136983

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Molecular Weight:

58.7 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human CLK2 Protein (Recombinant GST) (Full Length) - LS-G27950

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.52 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CLK2 Protein (Recombinant GST, N-terminus) (aa1-120) - LS-G58156

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CLK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78344

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.8 kDa

Price:

20 µg/$150

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CLK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100191

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.8 kDa

Price:

100 µg/$494

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