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CLCN4 / CLC-4

chloride channel, voltage-sensitive 4

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.

Gene Name: chloride channel, voltage-sensitive 4
Family/Subfamily: Ion Channel , Chloride channel - CLC
Synonyms: CLCN4, ClC-4, Chloride channel 4, Chloride channel protein 4, Chloride transporter ClC-4, ClC-4A, CLC4
Target Sequences: NM_001830 NP_001821.2 P51793

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Proteins (2)
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CLCN4 / CLC-4 (2)
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HEK 293 Cells (1)
CLCN4 / CLC-4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
84.7 kDa
100 µg/$710
CLCN4 / CLC-4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
84.7 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).