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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.

Gene Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Synonyms: CITED2, MRG1, MRG-1, MSG-related protein 1, ASD8, VSD2, MSG1-related gene 1, p35SRJ
Target Sequences: NM_006079 NP_006070.2 Q99967

Publications (9)

1
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Genes & development. 1999 13:64-75. [PubMed:9887100] [PMC:PMC316375]
2
Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. Tien ES, Davis JW, Vanden Heuvel JP. The Journal of biological chemistry. 2004 279:24053-63. [PubMed:15051727]
3
Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Bamforth SD, Bragana J, Farthing CR, Schneider JE, Broadbent C, Michell AC, Clarke K, Neubauer S, Norris D, Brown NA, Anderson RH, Bhattacharya S. Nature genetics. 2004 36:1189-96. [PubMed:15475956]
4
CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor. Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS. The Journal of endocrinology. 2007 192:459-65. [PubMed:17283246]
5
The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX, Hackenbeck T, Bernhardt W, Willam C, Eckardt KU, Wiesener MS. Experimental cell research. 2008 314:2016-27. [PubMed:18420194]
6
CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. Gonzalez YR, Zhang Y, Behzadpoor D, Cregan S, Bamforth S, Slack RS, Park DS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:5559-69. [PubMed:18495890]
7
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. The Journal of biological chemistry. 2011 286:7468-78. [PubMed:21159781] [PMC:PMC3045002]
8
CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance. Minemura H, Takagi K, Sato A, Takahashi H, Miki Y, Shibahara Y, Watanabe M, Ishida T, Sasano H, Suzuki T. Cancer science. 2016 107:1898-1908. (WB; Human) [Full Text Article] [PubMed:27627783] [PMC:PMC5198946] Related Antibodies: LS-B243.
9
Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2. Regel I, Merkl L, Friedrich T, Burgermeister E, Zimmermann W, Einw[Character e4]chter H, Herrmann K, Langer R, R[Character f6]cken C, Hofheinz R, Schmid R, Ebert MP. Gastroenterology. 2012 Jul;143:99-109.e10. [Full Text Article] [PubMed:22465428] Related Antibodies: LS-B243.
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Filtered By: None
Target
CITED2 (24)
Reactivity
Human (24)
Mouse (20)
Rat (11)
Bat (5)
Bovine (9)
Chicken (1)
Chimpanzee (6)
Gibbon (6)
Guinea pig (4)
Monkey (9)
Orangutan (6)
Pig (9)
Zebrafish (1)
Application
IHC (2)
IHC-P (2)
WB (23)
ELISA (9)
ICC (6)
IF (8)
Peptide-ELISA (1)
Host
rabbit (20)
mouse (2)
goat (1)
rat (1)
Isotype
IgG (18)
IgG1 (1)
IgG1,k (2)
IgG2a (1)
Clonality
monoclonal mc (3)
polyclonal pc (21)
Clone
11n47 (1)
JA22 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (12)
Epitope
aa200-226 (8)
N-Terminus (5)
aa55-104 (4)
C-Terminus (1)
aa1-269 (1)
aa158-169 (1)
Publications
No (23)
Yes (1)
Showing 1-24 of 24 results

CITED2 Antibody (clone JA22) IHC-plus™ LS-B243
Publications (2)
Publications (2)
Mouse Monoclonal [clone JA22] (IgG1,k) to Human CITED2
Human
IHC IHC-P WB
Unconjugated
100µl  $425.00
Anti-CITED2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Anti-CITED2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.

CITED2 Antibody (N-Terminus) LS-C80228
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
50µg  $365.00
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (N-Terminus, HRP) LS-C437454
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Bovine, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (N-Terminus, Biotin) LS-C437452
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Bovine, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (N-Terminus, FITC) LS-C437453
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Bovine, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (N-Terminus) IHC-plus™ LS-B8876
Rabbit Polyclonal (IgG) to Human CITED2
Human
IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-CITED2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunofluorescence of CITED2 in Jurkat cells with CITED2 antibody at 20 ug/ml.
Anti-CITED2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunofluorescence of CITED2 in Jurkat cells with CITED2 antibody at 20 ug/ml.

CITED2 Antibody (C-Terminus) LS-C79336
Mouse Monoclonal (IgG1,k) to Human CITED2
Human
WB
Unconjugated
100µl  $530.00

CITED2 Antibody (aa200-226) LS-C320405
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Human
ELISA IF WB
Unconjugated
200µl  $530.00

CITED2 Antibody (aa200-226, Biotin) LS-C213314
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Human
ELISA ICC IF WB
Biotin Conjugated
200µl  $680.00

CITED2 Antibody (aa200-226, FITC) LS-C213315
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Human
ELISA ICC IF WB
FITC Conjugated
200µl  $680.00

CITED2 Antibody (aa200-226, AP) LS-C213312
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Human
ELISA ICC IF WB
AP Conjugated
200µl  $680.00

CITED2 Antibody (aa200-226, Azide-free, HRP) LS-C213317
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Human
ELISA ICC IF WB
HRP Conjugated, Azide-free
200µl  $680.00

CITED2 Antibody (aa200-226, PE) LS-C213318
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Human
ELISA ICC IF WB
PE Conjugated
200µl  $680.00

CITED2 Antibody (aa200-226, APC) LS-C213313
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Human
ELISA ICC IF WB
APC Conjugated
200µl  $680.00

CITED2 Antibody LS-C658336
Rabbit Polyclonal (IgG1) to Human CITED2
Mouse, Rat, Human
ELISA WB
Unconjugated
100µg 1mg/ml  $485.00

CITED2 Antibody LS-C753196
Rabbit Polyclonal (IgG) to Human CITED2
Human
ELISA WB
Unconjugated
100µg  $355.00

CITED2 Antibody (aa1-269, clone 11n47) LS-C184204
Rat Monoclonal [clone 11n47] (IgG2a) to Mouse CITED2
Mouse, Human
WB
Unconjugated
100µg 500µl  $620.00

CITED2 Antibody (aa55-104) LS-C80129
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Guinea pig, Bovine, Rat, Pig, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (aa55-104, HRP) LS-C433159
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Guinea pig, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (aa55-104, Biotin) LS-C433156
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Guinea pig, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (aa55-104, FITC) LS-C433157
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Guinea pig, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CITED2 Antibody (aa200-226) LS-C168786
Rabbit Polyclonal to Human CITED2
Mouse, Human
WB
Unconjugated
400µl  $305.00
CITED2 Antibody western blot of mouse NIH-3T3 cell line lysates (15 ug/lane). The CITED2 antibody detected CITED2 protein (arrow).
CITED2 Antibody western blot of mouse NIH-3T3 cell line lysates (15 ug/lane). The CITED2 antibody detected CITED2 protein (arrow).

CITED2 Antibody LS-C747903
Rabbit Polyclonal (IgG) to Human CITED2
Mouse, Rat, Human
WB
Unconjugated
50µl  $235.00
Western blot analysis of extracts of various cell lines, using CITED2 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
Western blot analysis of extracts of various cell lines, using CITED2 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.

CITED2 Antibody (aa158-169) LS-C47568
Goat Polyclonal to Human CITED2
Chicken, Zebrafish, Pig, Bat, Mouse, Rat, Bovine, Human, Monkey
Peptide-ELISA
Unconjugated
100µg 0.5mg/ml  $335.00
Showing 1-24 of 24 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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