CILP

cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CILP (6)

Publications

No (6)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST, N-terminus (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CILP Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G136833

Source:

Baculovirus

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

55.7 kDa

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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Human CILP Protein (Recombinant GST, N-terminus) (aa129-226) - LS-G60738

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CILP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88413

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

132.62 kDa

Price:

20 µg/$150

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CILP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117200

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

132.62 kDa

Price:

100 µg/$494

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Human CILP Protein (Recombinant His-GST) (aa603-846) - LS-G14891

Source:

E. coli

Tag:

His-GST

Molecular Weight:

60.0 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse CILP Protein (Recombinant His-T7) (aa604-864) - LS-G14893

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.5 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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