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CHTF18 / RUVBL
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.
| Gene Name: | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) |
| Synonyms: | CHTF18, C16orf41, C321D2.2, C321D2.4, C321D2.3 (novel protein), Ctf18, HCTF18, Homolog of yeast CHL12, C321D2.3, C321D2.4 (novel protein), CHL12, RUVBL |
| Target Sequences: | Q8WVB6 Q8WVB6 |
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