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CHST5

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.

Gene Name:	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
Synonyms:	CHST5, GlcNAc6ST-3, GST4-alpha, Gn6st-3, HIGn6ST, I-GlcNAc-6-ST, I-GlcNAc6ST
Target Sequences:	NM_024533 NP_078809.2 Q9GZS9

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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