Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
CHRNE encodes the epsilon subunit of the nicotinic acetylcholine receptor (nAChR). The nAChR is an ion-conducting channel of the plasma membrane that transmits signal from motor neuron to skeletal muscle in response to binding acetylcholine. It is composed of four subunits in a stoichiometry of alpha 2, beta 1, delta 1, and gamma or epsilon 1. The epsilon subunit is a component of mature nAChRs, as it replaces the embryonic gamma subunit at neuromuscular junctions in newborns. CHRNE null mice display muscle weakness, defects in motor behavior, and premature death. Mutations in the CHRNE gene are responsible for slow-channel congenital myasthenic syndrome (SCCMS).
Gene Name: | cholinergic receptor, nicotinic, epsilon (muscle) |
Family/Subfamily: | Ion Channel , Nicotinic acetylcholine receptor |
Synonyms: | CHRNE, ACHRE, AChR-epsilon, AchR epsilon subunit, CMS1D, CMS1E, FCCMS, NAChR epsilon, SCCMS, CMS2A |
Target Sequences: | NM_000080 NP_000071.1 Q04844 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.