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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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CHRNA4 / NACHR
cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA4 / NACHR is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
| Gene Name: | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
| Family/Subfamily: | Ion Channel , Nicotinic acetylcholine receptor |
| Synonyms: | CHRNA4, BFNC, AChR-alpha4, Acra-4, EBN, EBN1, NACHR, NAChR alpha 4, NACRA4, NACHRA4, ENFL1 |
| Target Sequences: | NM_000744 NP_000735.1 P43681 |
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