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CHRNA3

cholinergic receptor, nicotinic, alpha 3 (neuronal)

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Gene Name: cholinergic receptor, nicotinic, alpha 3 (neuronal)
Family/Subfamily: Ion Channel , Nicotinic acetylcholine receptor
Synonyms: CHRNA3, AChR-alpha3, Acra-3, LNCR2, NAChR alpha 3, PAOD2, NACHRA3
Target Sequences: NM_000743 NP_000734.2 P32297

Publications (1)

1
Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Falvella FS, Galvan A, Frullanti E, Spinola M, Calabr E, Carbone A, Incarbone M, Santambrogio L, Pastorino U, Dragani TA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:1837-42. (IHC-P; Human) [PubMed:19223495] Related Antibodies: LS-B934.

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CHRNA3 ELISA Kit
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0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).