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CHRM3 / M3

cholinergic receptor, muscarinic 3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.

Gene Name: cholinergic receptor, muscarinic 3
Family/Subfamily: GPCR , Acetylcholine
Synonyms: CHRM3, M3, Muscarinic receptor M3, Muscarinic M3 receptor, EGBRS, HM3, M3 muscarinic receptor
Target Sequences: NM_000740 NP_000731.1 P20309

Publications (1)

1
Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands. Yiyu Wang, Jörg Scheffel, Carolina Ayala Vera, Wei Liu, Dorothee Günzel, Dorothea Terhorst-Molawi, Marcus Maurer, Sabine Altrichter. Frontiers in immunology. 2022 August;13:955161. [Full Text Article] [PubMed:35967390] [PMC:PMC9373796] Related Antibodies: LS-C144026.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
CHRM3 / M3 (5)
No (5)
6His-B2M, N-terminus (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (1)
CHRM3 / M3 Protein
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Yeast
His
28.6 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CHRM3 / M3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-B2M, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CHRM3 / M3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CHRM3 / M3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
65.9 kDa
20 µg/$215
CHRM3 / M3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
65.9 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).