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CHMP4C

charged multivesicular body protein 4C

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Name: charged multivesicular body protein 4C
Synonyms: CHMP4C, Chromatin modifying protein 4C, HVps32-3, Shax3, Vps32-3, VPS32C, SNF7-3, Chromatin-modifying protein 4c, HSnf7-3
Target Sequences: NM_152284 NP_689497.1 Q96CF2

☰ Filters
Antibodies (11)
Proteins (3)
Over-Expression Lysate (2)
Primary (11)
Recombinant (1)
CHMP4C (14)
Human (10)
Mouse (4)
IHC (1)
IHC-P (2)
WB (6)
ELISA (4)
rabbit (10)
mouse (1)
IgG (7)
polyclonal pc (11)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (5)
aa146-195 (4)
C-Terminus (1)
No (14)
Myc-DDK (Flag) (3)
Human (2)
293T Cells (1)
HEK 293 Cells (2)
CHMP4C Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHMP4C Rabbit anti-Mouse Polyclonal (aa146-195) Antibody
Mouse
WB
Unconjugated
100 µl/$424
CHMP4C Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHMP4C Rabbit anti-Mouse Polyclonal (aa146-195) (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$469
CHMP4C Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHMP4C Rabbit anti-Mouse Polyclonal (aa146-195) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$469
CHMP4C Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CHMP4C Rabbit anti-Mouse Polyclonal (aa146-195) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$469
CHMP4C Antibody - Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100
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CHMP4C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
CHMP4C Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
CHMP4C Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
CHMP4C Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
CHMP4C Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHMP4C (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with Rabbit polyclonal anti-CHMP4C antibody at 1:500 dilution.
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CHMP4C Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$414
CHMP4C Antibody - Immunochemical staining of human CHMP4C in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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CHMP4C Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
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CHMP4C Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
CHMP4C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.2 kDa
100 µg/$494
CHMP4C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
26.2 kDa
20 µg/$150
CHMP4C Protein - Purified recombinant protein CHMP4C was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
26.2 kDa
20 µg/$1,107
Viewing 1-14 of 14 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).