CHMP4A

charged multivesicular body protein 4A

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CHMP4A (4)

Publications

No (4)

Tag

His (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Purification

Purified (1)

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CHMP4A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114124

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.6 kDa

Price:

100 µg/$494

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Human CHMP4A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69410

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.6 kDa

Price:

20 µg/$1,107

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Human CHMP4A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84567

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.6 kDa

Price:

20 µg/$150

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Human CHMP4A Protein (Recombinant His) - LS-G1592

Source:

E. coli

Tag:

His

Price:

10 µg/$361; 50 µg/$739

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