CHD5

chromodomain helicase DNA binding protein 5

Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

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Products

ELISA Kits (5)

Type

Sandwich (5)

Target

CHD5 (5)

Reactivity

Human (2)

Mouse (1)

Rat (1)

Monkey (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (4)

Publications

No (5)

Sample Type

Plasma (4)

Serum (4)

Tissue Homogenates (1)

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Human CHD5 (Sandwich ELISA) ELISA Kit - LS-F23358

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

18.75 - 1200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Monkey CHD5 (Sandwich ELISA) ELISA Kit - LS-F42324

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

18.75 - 1200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Mouse CHD5 (Sandwich ELISA) ELISA Kit - LS-F38281

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Rat CHD5 (Sandwich ELISA) ELISA Kit - LS-F38604

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human CHD5 (Sandwich ELISA) ELISA Kit - LS-F56188

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

18.75 - 1200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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