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CHD3 is a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Gene Name: | chromodomain helicase DNA binding protein 3 |
Synonyms: | CHD3, ATP-dependent helicase CHD3, CHD-3, HZFH, Mi-2a, Mi2-ALPHA, ZFH, Zinc finger helicase |
Target Sequences: | U91543 AAC39923.1 Q12873 |
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