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CHAC1 / MGC4504
ChaC, cation transport regulator homolog 1 (E. coli)
Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.
| Gene Name: | ChaC, cation transport regulator homolog 1 (E. coli) |
| Synonyms: | CHAC1, BOTCH, MGC4504, Blocks Notch protein |
| Target Sequences: | NM_024111 NP_077016.2 Q9BUX1 |
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