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CFH / Complement Factor H

complement factor H

CFH / Complement Factor H is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: complement factor H
Synonyms: CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 (complement)
Target Sequences: NM_000186 NP_000177.2 P08603

Publications (6)

1
VEGF regulates local inhibitory complement proteins in the eye and kidney. The Journal of clinical investigation. 2017 January;127:199-214. [Full Text Article] [PubMed:27918307] [PMC:PMC5199702]
2
Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease. Guo Lu, Weihong Liu, Xinying Huang, Yanxin Zhao. Arquivos de neuro-psiquiatria. 2020 February;78:76-80. [Full Text Article] [PubMed:32022122]
3
Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site. Xiaocui Chen, Liqun Li, Fuhong Liu, Josephine Hoh, Carolyn M Kapron, Ju Liu. Journal of immunology (Baltimore, Md. : 1950). 2019 Feb;202:1210-1218. [Full Text Article] [PubMed:30642982]
4
Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS. Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Rossella Piras, Caterina Mele, Matteo Breno, Alessandra Cremaschi, Elena Bresin, Roberta Donadelli, Silvia Alizzi, Antonio Amoroso, Ariela Benigni, Giuseppe Remuzzi , Marina Noris. Frontiers in immunology. 2019 May;10:853. [Full Text Article] [PubMed:31118930] [PMC:PMC6504697] Related Antibodies: LS-C58560.
5
A Family Affair: Addressing the Challenges of Factor H and the Related Proteins10<sup> Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany. Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius , Antje J Baeumner, Mark-Steven Steiner, Mihály Józsi , Erik J M Toonen, Diana Pauly , SciFiMed consortium. Frontiers in immunology. 2021 Mar;12:660194. [Full Text Article] [PubMed:33868311] [PMC:PMC8044877]
6
CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis. Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J H Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris. Frontiers in genetics. 2021 Jun;12:670727. [Full Text Article] [PubMed:34211499] [PMC:PMC8240960] Related Antibodies: LS-C58560.
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Products
Proteins (14)
Native (1)
Over-Expression Lysate (2)
Recombinant (11)
CFH / Complement Factor H (14)
No (14)
6His, C-terminus (2)
GST (3)
His (4)
His,C-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Bovine (1)
Human (9)
Mouse (2)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (1)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (3)
Purified (6)
Low endotoxin level (4)
CFH / Complement Factor H Protein - Recombinant Complement Factor H By SDS-PAGE
Select
E. coli
His
43.2 kDa
10 µg/$260; 50 µg/$335; 100 µg/$497; 200 µg/$622; 1 mg/$1,588; 500 µg/$1,185; 5 mg/$2,522; 2 mg/$1,760
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.4 kDa
10 µg/$288; 50 µg/$436
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
43 kDa
100 µg/$721
CFH / Complement Factor H Protein - Recombinant Complement Factor H By SDS-PAGE
Select
E. coli
His
28.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CFH / Complement Factor H Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.02 kDa
100 µg/$710
CFH / Complement Factor H Protein - Recombinant Complement Factor H By SDS-PAGE
Select
E. coli
His
44.4 kDa
10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304
CFH / Complement Factor H Protein - 12.5% SDS-PAGE of human CFH stained with Coomassie Blue
Select
Wheat Germ Extract
GST
73.04 kDa
2 µg/$439
CFH / Complement Factor H Protein - 12.5% SDS-PAGE of human CFH stained with Coomassie Blue
Select
Wheat Germ Extract
GST
75.13 kDa
2 µg/$439
Select
Wheat Germ Extract
GST
47.19 kDa
2 µg/$439
Select
None
150 kDa
0.25 ml/$728
CFH / Complement Factor H Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.02 kDa
20 µg/$215
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50.0 kDa
10 µg/$344; 50 µg/$584
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
CFH / Complement Factor H Protein - Recombinant Complement Factor H By SDS-PAGE
Select
E. coli
His-T7
30.7 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).