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CES2 / Esterase

carboxylesterase 2

CES2 / Esterase is a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.

Gene Name: carboxylesterase 2
Synonyms: CES2, Carboxylesterase 2, CE-2, CES2A1, Cocaine esterase, Esterase, ICE, HCE-2, PCE-2
Target Sequences: NM_003869 NP_003860.2 O00748

Publications (1)

1
Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR. Verbrugge SE, Al M, Assaraf YG, Kammerer S, Chandrupatla DM, Honeywell R, Musters RP, Giovannetti E, O'Toole T, Scheffer GL, Krige D, de Gruijl TD, Niessen HW, Lems WF, Kramer PA, Scheper RJ, Cloos J, Ossenkoppele GJ, Peters GJ, Jansen G. Oncotarget. 2016 7:5240-57. (WB; Human) [Full Text Article] [PubMed:26496029] [PMC:PMC4868683] Related Antibodies: LS-B6190.

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Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
CES2 / Esterase (9)
No (9)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (6)
Human (6)
Mouse (1)
293T Cells (2)
HEK 293 Cells (4)
Human Cells (1)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
CES2 / Esterase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
66.9 kDa
100 µg/$710
CES2 / Esterase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
68.7 kDa
100 µg/$494
CES2 / Esterase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CES2 / Esterase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
68.7 kDa
20 µg/$150
CES2 / Esterase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
66.9 kDa
20 µg/$215
CES2 / Esterase Protein - Purified recombinant protein CES2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
68.7 kDa
20 µg/$1,107
CES2 / Esterase Protein - Purified recombinant protein CES2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
66.9 kDa
20 µg/$1,107
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
60.4 kDa
50 µg/$854
CES2 / Esterase Protein - 12.5% SDS-PAGE of human CES2 stained with Coomassie Blue
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Wheat Germ Extract
GST
95.3 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).