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CEP290

centrosomal protein 290kDa

CEP290 is a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.

Gene Name: centrosomal protein 290kDa
Synonyms: CEP290, 3H11Ag, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, CTCL tumor antigen se2-2, CT87, Centrosomal protein 290kDa, JBTS5, JBTS6, Meckel syndrome, type 4, Nephrocytsin-6, NPHP6, POC3, KIAA0373, Rd16, MKS4, SLSN6, BBS14, Nephrocystin-6, Prostate cancer antigen T21, Tumor antigen se2-2
Target Sequences: NM_025114 NP_079390.3 O15078

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Products
Antibodies (15)
Primary (15)
CEP290 (15)
Human (15)
Mouse (6)
Rat (1)
Bovine (1)
Monkey (1)
IHC (3)
IHC-P (2)
WB (8)
ELISA (7)
ICC (3)
IF (4)
IP (1)
Peptide-ELISA (4)
rabbit (13)
goat (2)
Product Group
IHCPlus (1)
IgG (10)
polyclonal pc (15)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (12)
aa2429-2479 (2)
740-820 aa, Internal (1)
C-Terminus (1)
Internal (1)
Phe812 (1)
aa1428-1440 (1)
aa521-535 (1)
aa771-820 (1)
No (15)
CEP290 Antibody - Anti-CEP290 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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CEP290 Rabbit anti-Human Polyclonal (aa771-820) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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CEP290 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
CEP290 Antibody - Immunohistochemistry of paraffin-embedded human ovarian cancer at dilution of 1:100
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CEP290 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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CEP290 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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CEP290 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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CEP290 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
CEP290 Antibody - Detection of Human CEP290 by Immunocytochemistry. Sample: NBF-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-CEP290 used at a dilution of 1:500. Detection: Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody DyLight 594 (A120-601D4) used at a dilution of 1:100.
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CEP290 Rabbit anti-Human Polyclonal (aa2429-2479) Antibody
Human
ICC, IF, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
CEP290 Antibody - Detection of Human CEP290 by Immunocytochemistry. Sample: NBF-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-CEP290 (-2) used at a dilution of 1:250. Detection: Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody DyLight 594 (A120-601D4) used at a dilution of 1:100.
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CEP290 Rabbit anti-Human Polyclonal (aa2429-2479) Antibody
Human
ICC, IF
Unconjugated
5 µg/$295; 100 µl/$532
CEP290 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CEP290 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CEP290 Antibody - Western blot of CEP290 antibody
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CEP290 Rabbit anti-Human Polyclonal (740-820 aa, Internal) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CEP290 Antibody - Western blot analysis of extracts from K562 cells, using CEP290 antibody.
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CEP290 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
CEP290 Antibody - Goat Anti-CEP290  Antibody (2.5ug/ml overnight staining of cell lines OPCT-1 (A) and MDA468 (fB) with Alexa Fluor 568 (red) and nuclear counter staining with DAPI (blue). Data kindly provided by Dr S, McArdle, and obtained by Sumanjeet Malhi, John van Geest Research Centre, Nottingham, UK
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CEP290 Goat anti-Human Polyclonal (aa521-535) Antibody
Human
ICC, Peptide-ELISA
Unconjugated
100 µg/$503
CEP290 Antibody - Western blot of CEP290 (F812) pAb in extracts from K562 cells.
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CEP290 Rabbit anti-Human Polyclonal (Phe812) Antibody
Mouse, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
CEP290 Antibody - Western blot analysis of CEP290 expression in HeLa (A); CCRFCEM (B) whole cell lysates.
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CEP290 Rabbit anti-Human Polyclonal (Internal) Antibody
Bovine, Human
WB
Unconjugated
100 µl/$299
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CEP290 Goat anti-Human Polyclonal (aa1428-1440) Antibody
Human, Monkey
Peptide-ELISA
Unconjugated
100 µg/$503
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).