Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
CEP290 is a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.
centrosomal protein 290kDa
CEP290, 3H11Ag, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, CTCL tumor antigen se2-2, CT87, Centrosomal protein 290kDa, JBTS5, JBTS6, Meckel syndrome, type 4, Nephrocytsin-6, NPHP6, POC3, KIAA0373, Rd16, MKS4, SLSN6, BBS14, Nephrocystin-6, Prostate cancer antigen T21, Tumor antigen se2-2