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Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.
Gene Name: | centrosomal protein 152kDa |
Synonyms: | CEP152, Centrosomal protein of 152 kDa, Centrosomal protein 152kDa, KIAA0912, MCPH9, MCPH4, SCKL5, Asterless |
Target Sequences: | AB020719 BAA74935.1 O94986 |
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