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CELF3
CUGBP, Elav-like family member 3
RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
| Gene Name: | CUGBP, Elav-like family member 3 |
| Synonyms: | CELF3, CELF-3, CAG repeat protein 4, CAGH4, ETR-1, ERDA4, RNA-binding protein BRUNOL-1, TNRC4, Bruno-like protein 1, BRUNOL1, CAG repeat domain, CUG-BP and ETR-3 like factor 3 |
| Target Sequences: | NM_007185 NP_009116.3 Q5SZQ8 |
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