CELF2 / CUGBP2

CUGBP, Elav-like family member 2

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats.

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Proteins (10)

Type

Over-Expression Lysate (6)

Recombinant (4)

Target

CELF2 / CUGBP2 (10)

Publications

No (10)

Tag

GST (2)

Myc-DDK (Flag) (8)

Species

Human (7)

Source

293T Cells (3)

HEK 293 Cells (5)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CELF2 / CUGBP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65570

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

20 µg/$1,107

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Human CELF2 / CUGBP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65572

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

20 µg/$1,107

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CELF2 / CUGBP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115223

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

100 µg/$710

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CELF2 / CUGBP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119812

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

100 µg/$710

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CELF2 / CUGBP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121120

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.1 kDa

Price:

100 µg/$710

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Human CELF2 / CUGBP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75816

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.1 kDa

Price:

20 µg/$215

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Human CELF2 / CUGBP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75817

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.9 kDa

Price:

20 µg/$215

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Human CELF2 / CUGBP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75818

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

20 µg/$215

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Human CELF2 / CUGBP2 Protein (Recombinant GST) - LS-G132143

Tag:

GST

Molecular Weight:

37.73kDa

Price:

10 µg/$479; 25 µg/$670

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Human CELF2 / CUGBP2 Protein (Recombinant GST) (Full Length) - LS-G32286

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

82.2 kDa

Price:

10 µg/$479; 25 µg/$670

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