LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

CELF1 / CUGBP1

CUGBP, Elav-like family member 1

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.

Gene Name: CUGBP, Elav-like family member 1
Synonyms: CELF1, Bruno-like protein 2, BRUNOL2, Bruno-like 2, CELF-1, CUG RNA-binding protein, CUGBP1, CUG-BP, EDEN-BP, HNab50, NAB50, NAPOR, RNA-binding protein BRUNOL-2, CUG-BP1, CUGBP, Deadenylation factor CUG-BP, EDEN-BP homolog
Target Sequences: NM_006560 NP_006551.1 Q92879

Publications (9)

1
A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. Good PJ, Chen Q, Warner SJ, Herring DC. The Journal of biological chemistry. 2000 275:28583-92. [PubMed:10893231]
2
Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2. Mankodi A, Teng-Umnuay P, Krym M, Henderson D, Swanson M, Thornton CA. Annals of neurology. 2003 54:760-8. [PubMed:14681885]
3
Nuclear RNA foci in the heart in myotonic dystrophy. Mankodi A, Lin X, Blaxall BC, Swanson MS, Thornton CA. Circulation research. 2005 97:1152-5. (IHC) [PubMed:16254211]
4
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Lin X, Miller JW, Mankodi A, Kanadia RN, Yuan Y, Moxley RT, Swanson MS, Thornton CA. Human molecular genetics. 2006 15:2087-97. (ICC, WB; Mouse, Human) [PubMed:16717059]
5
Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice. Kress C, Gautier-Courteille C, Osborne HB, Babinet C, Paillard L. Molecular and cellular biology. 2007 27:1146-57. [PubMed:17130239] [PMC:PMC1800704]
6
Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Orengo JP, Chambon P, Metzger D, Mosier DR, Snipes GJ, Cooper TA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:2646-51. [PubMed:18272483] [PMC:PMC2268190]
7
Ectopic expression of CGG containing mRNA is neurotoxic in mammals. Hashem V, Galloway JN, Mori M, Willemsen R, Oostra BA, Paylor R, Nelson DL. Human molecular genetics. 2009 18:2443-51. [PubMed:19377084] [PMC:PMC2694692]
8
CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Ward AJ, Rimer M, Killian JM, Dowling JJ, Cooper TA. Human molecular genetics. 2010 19:3614-22. [PubMed:20603324] [PMC:PMC2928132]
9
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. Xiao Q, Ford AL, Xu J, Yan P, Lee KY, Gonzales E, West T, Holtzman DM, Lee JM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:13587-96. (ICC, IHC, WB, GS; Mouse, Rat) [PubMed:23015448] [PMC:PMC3482490]
more

Filtered By: None
Target
CELF1 / CUGBP1 (33)
Reactivity
Human (33)
Mouse (24)
Rat (16)
Bovine (14)
Chicken (5)
Chimpanzee (3)
Dog (4)
Guinea pig (4)
Horse (4)
Monkey (4)
Orangutan (3)
Pig (9)
Rabbit (13)
Xenopus (4)
Zebrafish (5)
Application
IHC (16)
IHC-P (8)
WB (32)
ELISA (9)
ICC (8)
IF (3)
IP (7)
Peptide-ELISA (1)
Host
rabbit (23)
mouse (10)
Isotype
IgG (24)
IgG1,k (2)
IgG2b (1)
Clonality
monoclonal mc (10)
polyclonal pc (23)
Clone
3B1 (1)
5B8 (1)
Format
AP Conjugated (3)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (12)
Epitope
aa1-30 (8)
aa120-169 (4)
40-120 aa, Internal (1)
Internal (1)
aa71-120 (1)
Publications
No (33)
Showing 1-25 of 33 results

CELF1 / CUGBP1 Antibody (aa120-169) IHC-plus™ LS-B5702
Rabbit Polyclonal to Human CELF1 / CUGBP1
Xenopus, Chicken, Zebrafish, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg  $485.00
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CELF1 / CUGBP1 Antibody (aa120-169, HRP) LS-C440105
Rabbit Polyclonal to Human CELF1 / CUGBP1
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CELF1 / CUGBP1 Antibody (aa120-169, Biotin) LS-C440103
Rabbit Polyclonal to Human CELF1 / CUGBP1
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CELF1 / CUGBP1 Antibody (aa120-169, FITC) LS-C440104
Rabbit Polyclonal to Human CELF1 / CUGBP1
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CELF1 / CUGBP1 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CELF1 / CUGBP1 Antibody (clone 3B1) IHC-plus™ LS-B216
Mouse Monoclonal [clone 3B1] (IgG1,k) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
IF IHC IHC-P WB
Unconjugated
100µl  $425.00
Anti-CELF1 / CUGBP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-CELF1 / CUGBP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CELF1 / CUGBP1 Antibody (clone 5B8) LS-C115006
Mouse Monoclonal [clone 5B8] (IgG2b) to Human CELF1 / CUGBP1
Human
IF IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-CUGBP1 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Kidney tissue using anti-CUGBP1 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-CUGBP1 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Kidney tissue using anti-CUGBP1 mouse monoclonal antibody. (Dilution 1:50).

CELF1 / CUGBP1 Antibody (Internal) LS-C353283
Rabbit Polyclonal to Human CELF1 / CUGBP1
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of CUGBP1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of CUGBP1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Immunohistochemical analysis of CUGBP1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of CUGBP1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

CELF1 / CUGBP1 Antibody (aa1-30) LS-C320684
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Human
ELISA IHC WB
Unconjugated
200µl  $530.00

CELF1 / CUGBP1 Antibody (aa1-30, Biotin) LS-C213469
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

CELF1 / CUGBP1 Antibody (aa1-30, FITC) LS-C213470
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

CELF1 / CUGBP1 Antibody (aa1-30, APC) LS-C213467
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

CELF1 / CUGBP1 Antibody (aa1-30, AP) LS-C213468
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

CELF1 / CUGBP1 Antibody (aa1-30, PE) LS-C213472
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

CELF1 / CUGBP1 Antibody (aa1-30, Azide-free, HRP) LS-C213471
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

CELF1 / CUGBP1 Antibody (40-120 aa, Internal) LS-C382946
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of CUG-BP1 antibody
Western blot of CUG-BP1 antibody

CELF1 / CUGBP1 Antibody LS-C22462
Mouse Monoclonal (IgG) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC IP WB
Unconjugated
200µg 1mg/ml  $605.00

CELF1 / CUGBP1 Antibody (HRP) LS-C545413
Mouse Monoclonal (IgG) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC IP WB
HRP Conjugated
100µl  $755.00

CELF1 / CUGBP1 Antibody (Biotin) LS-C525295
Mouse Monoclonal (IgG) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC IP WB
Biotin Conjugated
100µl  $755.00

CELF1 / CUGBP1 Antibody (FITC) LS-C535310
Mouse Monoclonal (IgG) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC IP WB
FITC Conjugated
100µl  $755.00

CELF1 / CUGBP1 Antibody (AP) LS-C507327
Mouse Monoclonal (IgG) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC IP WB
AP Conjugated
100µl  $755.00

CELF1 / CUGBP1 Antibody (APC) LS-C516221
Mouse Monoclonal (IgG) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC IP WB
APC Conjugated
100µl  $755.00

CELF1 / CUGBP1 Antibody (PE) LS-C653493
Mouse Monoclonal (IgG) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC IP WB
PE Conjugated
100µl  $755.00

CELF1 / CUGBP1 Antibody (aa1-30) LS-C167156
Rabbit Polyclonal to Human CELF1 / CUGBP1
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
CUGBP1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
CUGBP1 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The CUGBP1 antibody detected the CUGBP1 protein (arrow).
CUGBP1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
CUGBP1 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The CUGBP1 antibody detected the CUGBP1 protein (arrow).

CELF1 / CUGBP1 Antibody (aa71-120) LS-C119189
Rabbit Polyclonal (IgG) to Human CELF1 / CUGBP1
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HeLa and HepG2 cells, using CELF-1 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HeLa and HepG2 cells, using CELF-1 Antibody. The lane on the right is blocked with the synthesized peptide.

CELF1 / CUGBP1 Antibody LS-C22463
Mouse Monoclonal (IgG1,k) to Human CELF1 / CUGBP1
Rabbit, Mouse, Bovine, Rat, Pig, Human
ELISA
Unconjugated
100µl  $590.00
Showing 1-25 of 33 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Get Social With Us!
Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy