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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.
Gene Name: | chymotrypsin-like elastase family, member 2A |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | CELA2A, Elastase IIA, Elastase 2A, ELA2A, PE-1, Pancreatic elastase 2, Pancreatic elastase 2a, Elastase-2A, Pancreatic elastase IIA, Peiia |
Target Sequences: | NM_033440 NP_254275.1 P08217 |
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