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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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CDK3
cyclin-dependent kinase 3
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
| Gene Name: | cyclin-dependent kinase 3 |
| Family/Subfamily: | Protein Kinase , CDC2/CDK |
| Synonyms: | CDK3, Cell division protein kinase 3, Cell division kinase 3, Cyclin-dependent kinase 3 |
| Target Sequences: | NM_001258 NP_001249.1 Q00526 |
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