CDK2AP1 / DOC1

cyclin-dependent kinase 2 associated protein 1

CDK2AP1 is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

CDK2AP1 / DOC1 (7)

Publications

No (7)

Tag

GST (2)

His (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human CDK2AP1 / DOC1 Protein (Recombinant) (Met1-Ser115) - LS-G133616

Source:

E. coli

Tag:

None

Molecular Weight:

16.1kDa

Price:

10 µg/$249; 50 µg/$307; 200 µg/$482; 100 µg/$385; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480

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Human CDK2AP1 / DOC1 Protein (Recombinant GST) (Full Length) - LS-G20591

Source:

E. coli

Tag:

GST

Molecular Weight:

39.8 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CDK2AP1 / DOC1 Protein (Recombinant GST) (Full Length) - LS-G31068

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.39 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CDK2AP1 / DOC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67425

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.2 kDa

Price:

20 µg/$1,107

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Human CDK2AP1 / DOC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79813

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.2 kDa

Price:

20 µg/$150

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CDK2AP1 / DOC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100356

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.2 kDa

Price:

100 µg/$494

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Human CDK2AP1 / DOC1 Protein (Recombinant His) - LS-G701

Source:

E. coli

Tag:

His

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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