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CDK19 / CDK11 encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene Name: | cyclin-dependent kinase 19 |
Family/Subfamily: | Protein Kinase , CDC2/CDK |
Synonyms: | CDK19, BA346C16.3, CDC2L6, CDK11, CDC2-related protein kinase 6, Cyclin-dependent kinase 19, Cyclin-dependent kinase 11, Death-preventing kinase, KIAA1028 |
Target Sequences: | AY028424 AAK27731.1 Q9BWU1 |
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