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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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CDK11B / CDC2L1
cyclin-dependent kinase 11B
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.
| Gene Name: | cyclin-dependent kinase 11B |
| Family/Subfamily: | Protein Kinase , PITSLRE |
| Synonyms: | CDK11B, CDK11, CDC-related protein kinase p58, CLK-1, Cyclin-dependent kinase 11B, CDC2L1, CDK11-p110, CDK11-p58, Cell division cycle 2-like 1, p58, p58 CLK-1, p58CLK-1, PITSLRE protein kinase alpha, PITSLRE B, PK58, PITSLREA, CDK11-p46, p58CDC2L1, Protein kinase p58, Protein kinase p58/gta |
| Target Sequences: | NM_033486 NP_277021.2 P21127 |
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