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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CDK11B / CDC2L1

cyclin-dependent kinase 11B

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.

Gene Name: cyclin-dependent kinase 11B
Family/Subfamily: Protein Kinase , PITSLRE
Synonyms: CDK11B, CDK11, CDC-related protein kinase p58, CLK-1, Cyclin-dependent kinase 11B, CDC2L1, CDK11-p110, CDK11-p58, Cell division cycle 2-like 1, p58, p58 CLK-1, p58CLK-1, PITSLRE protein kinase alpha, PITSLRE B, PK58, PITSLREA, CDK11-p46, p58CDC2L1, Protein kinase p58, Protein kinase p58/gta
Target Sequences: NM_033486 NP_277021.2 P21127

Filtered By: None
Target
CDK11B / CDC2L1 (8)
Reactivity
Human (8)
Mouse (6)
Rat (2)
Bovine (1)
Chicken (1)
Pig (1)
Application
IHC (4)
IHC-P (1)
WB (7)
ELISA (1)
IP (1)
Peptide-ELISA (1)
Host
rabbit (8)
Isotype
IgG (5)
Clonality
polyclonal pc (8)
Format
Unconjugated (8)
Epitope
10-90 aa, N-terminal (1)
Lys20 (1)
N-Terminus (1)
aa10-59 (1)
aa730-780 (1)
Publications
No (8)
Showing 1-8 of 8 results

CDK11B / CDC2L1 Antibody (10-90 aa, N-terminal) LS-C385504
Rabbit Polyclonal (IgG) to Human CDK11B / CDC2L1
Mouse, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of PITSLRE antibody
Western blot of PITSLRE antibody

CDK11B / CDC2L1 Antibody (N-Terminus) LS-C368648
Rabbit Polyclonal to Human CDK11B / CDC2L1
Chicken, Bovine, Rat, Pig, Mouse, Human
IHC IHC-P WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Immunohistochemical analysis of CDK11B staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of CDK11B expression in HepG2 (A); HeLa (B) whole cell lysates.
Immunohistochemical analysis of CDK11B staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of CDK11B expression in HepG2 (A); HeLa (B) whole cell lysates.

CDK11B / CDC2L1 Antibody (Lys20) LS-C191943
Rabbit Polyclonal to Human CDK11B / CDC2L1
Mouse, Human
IHC WB
Unconjugated
100µl  $345.00

CDK11B / CDC2L1 Antibody (aa730-780) LS-C128064
Rabbit Polyclonal (IgG) to Human CDK11B / CDC2L1
Human
IP WB
Unconjugated
50µg  $560.00

CDK11B / CDC2L1 Antibody (aa10-59) LS-C118818
Rabbit Polyclonal (IgG) to Human CDK11B / CDC2L1
Mouse, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HUVEC and HepG2 cells, using CDC2L1 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HUVEC and HepG2 cells, using CDC2L1 Antibody. The lane on the right is blocked with the synthesized peptide.

CDK11B / CDC2L1 Antibody LS-C749697
Rabbit Polyclonal (IgG) to Human CDK11B / CDC2L1
Mouse, Rat, Human
IHC
Unconjugated
50µl  $235.00

CDK11B / CDC2L1 Antibody LS-C394142
Rabbit Polyclonal to Human CDK11B / CDC2L1
Human
WB
Unconjugated
100µl  $305.00
All lanes: Anti-CDK11B Antibody at 1:1000 dilution. Lane 1: HeLa whole cell lysate. Lane 2: 293T/17 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 93 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
All lanes: Anti-CDK11B Antibody at 1:1000 dilution. Lane 1: HeLa whole cell lysate. Lane 2: 293T/17 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 93 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

CDK11B / CDC2L1 Antibody LS-C747900
Rabbit Polyclonal (IgG) to Human CDK11B / CDC2L1
Mouse, Human
WB
Unconjugated
50µl  $235.00
Western blot analysis of extracts of various cell lines, using CDK11B Antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Western blot analysis of extracts of various cell lines, using CDK11B Antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Showing 1-8 of 8 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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