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CDH20 / Cadherin 20 is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.
Gene Name: | cadherin 20, type 2 |
Family/Subfamily: | Cadherin , not assigned-Cadherin |
Synonyms: | CDH20, Cadherin 20, type 2, CDH7L3, Cadherin-20 |
Target Sequences: | NM_031891 NP_114097.2 Q9HBT6 |
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