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CDH12 / Cadherin 12

cadherin 12, type 2 (N-cadherin 2)

CDH12 / Cadherin 12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Gene Name: cadherin 12, type 2 (N-cadherin 2)
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: CDH12, Brain cadherin, Cadherin-12, Br-cadherin, Brain-cadherin, Cadherin, neural type, 2, CDHB, N-cadherin 2, Neural type cadherin 2, Neuronal cadherin 2
Target Sequences: NM_004061 NP_004052.2 P55289

Publications (1)

1
An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer10<sup> Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. simon.knott@cshs.org12<sup> Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. dan.theodorescu@cshs.org. Kenneth H Gouin rd # , Nathan Ing # , Jasmine T Plummer , Charles J Rosser , Bassem Ben Cheikh , Catherine Oh , Stephanie S Chen , Keith Syson Chan , Hideki Furuya , Warren G Tourtellotte , Simon R V Knott , Dan Theodorescu. Nature communications. 2021 Aug;12:4906. [Full Text Article] [PubMed:34385456] [PMC:PMC8361097] Related Antibodies: LS-B11408.

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Proteins (6)
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CDH12 / Cadherin 12 (6)
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GST, N-terminus (1)
His (2)
Myc-DDK (Flag) (2)
Human (5)
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CDH12 / Cadherin 12 Protein - 12.5% SDS-PAGE of human CDH12 stained with Coomassie Blue
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Wheat Germ Extract
GST
114.7 kDa
2 µg/$439
CDH12 / Cadherin 12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
88.2 kDa
100 µg/$494
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E. coli
His
64.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CDH12 / Cadherin 12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
88.2 kDa
20 µg/$150
CDH12 / Cadherin 12 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
66 kDa
100 µg/$721
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).