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CDH12 / Cadherin 12
cadherin 12, type 2 (N-cadherin 2)
CDH12 / Cadherin 12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
| Gene Name: | cadherin 12, type 2 (N-cadherin 2) |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | CDH12, Brain cadherin, Cadherin-12, Br-cadherin, Brain-cadherin, Cadherin, neural type, 2, CDHB, N-cadherin 2, Neural type cadherin 2, Neuronal cadherin 2 |
| Target Sequences: | NM_004061 NP_004052.2 P55289 |
Publications (1)
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